Perioperatif Kemoterapi Alan Lokal �leri Mide Kanserli Hastalarda Psoas Kas �ndeksinin Klinik �nemi

Ayd�ner, �mer; Do�an, Akif; Alan, �zkan; Y�ld�r�m, Sedat; Akda�, Goncag�l; Ya�ar, Zeynep Y�ksel; Y�ld�r�m, Mahmut Emre; Karadayi Buyukozsoy, Aysegul; Odabas, Hatice; Turan, Nedim

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Perioperatif Kemoterapi Alan Lokal �leri Mide Kanserli Hastalarda Psoas Kas �ndeksinin Klinik �nemi [South Clin Ist Euras]

South Clin Ist Euras. 2023; 34(3): 205-213 | DOI: 10.14744/scie.2023.94695

Perioperatif Kemoterapi Alan Lokal �leri Mide Kanserli Hastalarda Psoas Kas �ndeksinin Klinik �nemi

�mer Ayd�ner¹, Akif Do�an², �zkan Alan³, Sedat Y�ld�r�m², Goncag�l Akda�², Zeynep Y�ksel Ya�ar², Mahmut Emre Y�ld�r�m², Aysegul Karadayi Buyukozsoy¹, Hatice Odabas², Nedim Turan²
¹Sa�l�k Bilimleri �niversitesi Kartal Dr. L�tfi K�rdar �ehir Hastanesi, Radyoloji B�l�m�, �stanbul T�rkiye
²Sa�l�k Bilimleri �niversitesi Kartal Dr. L�tfi K�rdar �ehir Hastanesi, T�bbi Onkoloji B�l�m�, �stanbul T�rkiye
³Ko� �niversitesi T�p Fak�ltesi, T�bbi Onkoloji Anabilim Dal�, �stanbul, T�rkiye

G�R�� ve AMA�: Lokal ileri mide kanserinde (L�MK) evreleme i�in yap�lan rutin bilgisayarl� tomografide (BT) tek kas �l��m� ile elde edilen psoas kas indeksi (PMI), t�m v�cut sarkopenisini �ng�rmede yard�mc�d�r. Bu �al��ma ile amac�m�z PMI ile genel sa�kal�m (GSK) ve hastal�ks�z sa�kal�m (HSK) aras�ndaki ili�kiyi belirlemektir.
Y�NTEM ve GERE�LER: Bu retrospektif kohort, Ocak 2015 ile Aral�k 2021 aras�nda merkezimizde perioperatif kemoterapi ve k�ratif cerrahi uygulanan L�MK�li 122 hasta ile ger�ekle�tirildi. PMI ve Psoas kas yo�unlu�u (PMD), evreleme i�in yap�lan rutin BT kullan�larak L3 vertebra seviyesinde hesapland�. LAGC tan�s�ndan sonra, OS ve DFS ile ili�kisi incelendi.
BULGULAR: 122 hastan�n 29�u kad�nd�. FLOT en yayg�n kemoterapi rejimiydi ve en s�k total gastrektomi uyguland�. PMI de�erlerine g�re hastalar iki gruba ayr�ld�. Y�ksek PMI grubunda OS ve DFS ula��lamazken, d��k PMI grubunda OS ve PFS s�ras�yla 19 ve PFS 16 ay olarak belirlendi. �ki sa�kal�m parametresi a��s�ndan y�ksek ve d��k PMI gruplar� aras�nda istatistiksel olarak anlaml� fark vard� (s�ras�yla, p=0.03 ve p=0.001).
TARTI�MA ve SONU�: L�MK tan�l� hastalarda evreleme amac�yla yap�lan BT�de �l��len PMI, hastal��n prognozunu tahmin etmede �nemli ve pratik bir y�ntemdir.

Anahtar Kelimeler: Bilgisayarl� tomografi, mide kanseri, perioperatif tedavi, psoas kas indeksi.

Clinical Significance of the Psoas Muscle Index in Patients with Locally Advanced Gastric Cancer Receiving Perioperative Chemotherapy

�mer Ayd�ner¹, Akif Do�an², �zkan Alan³, Sedat Y�ld�r�m², Goncag�l Akda�², Zeynep Y�ksel Ya�ar², Mahmut Emre Y�ld�r�m², Aysegul Karadayi Buyukozsoy¹, Hatice Odabas², Nedim Turan²
¹Department of Radiology, University of Health Sciences, Kartal Dr. Lütfi K�rdar City Hospital, �stanbul, Türkiye
²Department of Medical Oncology, University of Health Sciences, Kartal Dr. Lütfi K�rdar City Hospital, �stanbul, Türkiye
³Division of Medical Oncology, School of Medicine, Ko� University, �stanbul, Türkiye

INTRODUCTION: The psoas muscle index (PMI) obtained with a single muscle measurement on routine computed tomography (CT) performed for staging in locally advanced gastric cancer (LAGC) is helpful in predicting whole-body sarcopenia. The objective of this trial was to determine the relationship between PMI and overall survival (OS) and disease-free survival (DFS).
METHODS: This retrospective cohort was conducted with 122 patients with LAGC who underwent perioperative chemotherapy and curative surgery in our center between January 2015 and December 2021. PMI and psoas muscle density were calculated at the L3 vertebra level using routine CT performed for staging after the LAGC diagnosis, and its relationship with OS and DFS was examined.
RESULTS: Twenty-nine of 122 patients were women. FLOT was the most common chemo-therapy regimen and total gastrectomy was performed most frequently. The patients were divided into two groups according to the PMI values. OS and DFS were unachievable in the high PMI group, while OS and PFS were determined as 19 and 16 months, respectively, in the low PMI group. There was a statistically significant difference between the high and low PMI groups in terms of the two survival parameters (p=0.03 and p=0.001, respectively).
DISCUSSION AND CONCLUSION: PMI measured on CT performed for staging in patients diagnosed with LAGC is an important and practical method in predicting the prognosis of the disease.

Keywords: Computed tomography, gastric cancer, perioperative treatment, psoas muscle index.

�mer Ayd�ner, Akif Do�an, �zkan Alan, Sedat Y�ld�r�m, Goncag�l Akda�, Zeynep Y�ksel Ya�ar, Mahmut Emre Y�ld�r�m, Aysegul Karadayi Buyukozsoy, Hatice Odabas, Nedim Turan. Clinical Significance of the Psoas Muscle Index in Patients with Locally Advanced Gastric Cancer Receiving Perioperative Chemotherapy. South Clin Ist Euras. 2023; 34(3): 205-213

Sorumlu Yazar: Akif Do�an, T�rkiye
Makale Dili: �ngilizce

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