South Clin Ist Euras. 2012; 23(1): 25-29 | DOI: 10.5505/jkartaltr.2012.26818

Glioblastome multiformede tedavi seçenekleri ve yaþam sürelerine etkileri

Ali Yýlmaz¹, Filiz Altuð², Engin Düz¹, Bayram Çýrak^1
1Pamukkale Üniversitesi Týp Fakültesi, Beyin Cerrahisi Anabilim Dalý, Denizli
²Pamukkale Üniversitesi, Fizik Tedavi ve Rehabilitasyon Yüksekokulu, Denizli

AMAÇ: Glioblastoma multiforme (GBM) yetiþkinlerde en sýk görülen maling primer beyin tümörüdür. Taný ve tedavisi oldukça zordur. Sýk görülmesine raðmen GBM’de tedavi seçenekleri çok fazla deðiþmemiþtir. Bu çalýþma, GBM’li hastalarda tedavi seçeneklerinin yaþam sürelerine etkisini incelemek amacýyla planlandý.
YÖNTEMLER: Bu çalýþmada nöroþirürji kliniðinde taný, tedavi ve izlemleri yapýlan 32 GBM’li hasta (16 erkek, 16 kadýn) geriye dönük olarak deðerlendirildi. Olgulara hastalýk hakkýnda ve uygulanan tedavi yöntemleri hakkýnda bilgi verildi. Hastalarýn performans durumunu belirlemek için Karnofsky performans skalasý kullanýldý, saðkalým süreleri kaydedildi.
BULGULAR: Hastalarýn yaþ medyan deðeri 64 yýl, takip süresi medyan deðeri 7.5 ay ve performans ortalamasý 59.06±9.95 olarak bulundu.
SONUÇ: Bu çalýþmanýn sonucunda GBM’li hastalarda, hastalarýn performans durumlarýnýn prognostik faktörleri etkilediði görülmüþtür.

Anahtar Kelimeler: Glioblastome multiforme, radyoterapi, kemoterapi, Karnofsky performans skalasý

---

Treatment options and effects of survival in glioblastoma multiforme

Ali Yýlmaz¹, Filiz Altuð², Engin Düz¹, Bayram Çýrak^1
1Pamukkale University Faculty of Medicine, Department of Neurosurgery, Denizli, Turkey
²Pamukkale University, School of Physical Therapy and Rehabilitation, Denizli, Turkey

OBJECTIVE: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. They are difficult to diagnose and challenging to treat. Treatment options for GBM have not changed over the years despite its high frequency in patients. This study was planned to examine the effects of treatment options on the duration of life in patients with GBM.
METHODS: In this study, we retrospectively evaluated 32 patients (16 male, 16 female) with a GBM diagnosis who were treated in the department of neurosurgery. All of the patients were informed about the disease and the treatment modalities. The Karnofsky performance scale was used to evaluate performance status and survival times were noted.
RESULTS: The median age was 64 years, the median follow–up duration was 7.5 months and the mean of performance status was 59.06±9.95.
CONCLUSION: The results of this study indicate that the performance status of patients diagnosed with GBM is in close relation to their initial prognosis.

Keywords: Glioblastoma multiforme, radiotherapy, chemotherapy, Karnofsky performance scale

---

ATIF KOPYALA