DUODENAL ÜLSER, GASTRÝTÝS, ÜLSERSÝZ DÝSPEPSÝDE HELÝCOBACTER PYLORÝ SIKLIÐI

1983'te Helicobacter pylori'nin tanýmlanmasý, gastroenterolojik literatüre yeni bir boyut kazandýrmýþtýr. Midenin Helicobacter pylori ile kolonizasyonunun gastrit, peptik ülser ve mide kanseri etyopatogenezinde rolü olduðu artýk kabul edilmektedir. Helicobacter pylori bol miktarda üreaz enzimi oluþturmaktadýr. Bu enzimin mide mukozasýnda tesbiti bakteri ile enfeksiyonu gösterir. Bu çalýþmada mide mukoza biyopsilerinde Helicobacter pylori enfeksiyonunu tespit etmek için Üreaz Test (CLO test) kullanýlarak klinik ve endoskopik bulgularla Üreaz test sonuçlan karþýlaþtýrýldý. Bu amaçla klinik ve polikliniðimize gastrit, ülser ve nonülser dispepsi yakýnmalarý ile baþvuran 50 hastaya gastroduodenoskopi yapýldý. Her hastadan prepilorik antrum biyopsisi alýnarak dokuda üreaz aktivitesi ölçüldü. Duodenal ülserli 25 hastanýn 23'ünde (%92), gastrit ve nonülser dispepsili 25 hastanýn 19'unda (%76) üreaz testi pozitif bulundu. Sonuçlar toplumumuzda Helicobacter pylori Ýnfeksiyonunun yaygýnlýðýný göstermektedir.

THE FREQUENCY OF HELICOBACTER PYLORI IN DUODENAL ULCER, GASTRITIS, NON-ULCER DYSPEPSIA

With the description of Helicobacter pylori in 1983, the gastroenterologic: literature has spawned a new structure. Helicobacter pylori colonisation of the stomach may be an etiological factor in gastritis, peptic ulcer and gastric carcinoma. Helicobacter pylori produces a large amount of urease, and the presence of this enzyme in gastric mucosa usually indicates the infection with the organism, in this study, CLO test was used to detect the Helicobacter pylori infection at gastric mucosa biopsies and the results of CLO test were compared with clinic and endoscopic findings. For this purpose 50 patients with gastritis, peptic ulcer or non-ulcer dyspepsia, were examined with upper gastroinlestinal endoscopie. Urease activity was measured with CLO test at antral biopsy of each patient. Urease test was positive in 23 out of 25 patients with duodenal ulcer (%92) and in 19 out of 25 patients with gastritis and non ulcer dyspepsia (%76). The results of the study suggest that the Helicobacter pylori infection is common in our society.