Derin anemi ve yayg�n lenfadenomegali ile kendini g�steren sistemik lupus eritematozus olgusu

Demirel Y�ld�r�m, Naciye; Ayd�n, Demet; Mert, Meral; Tuna, Sava�; B��akc�, Ercan; Nal�ac�, Meliha; Do�an, �ner

Cilt : 36 Say� : 1 Y�l : 2025

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Derin anemi ve yayg�n lenfadenomegali ile kendini g�steren sistemik lupus eritematozus olgusu [South Clin Ist Euras]

South Clin Ist Euras. 2009; 20(2): 90-94

Derin anemi ve yayg�n lenfadenomegali ile kendini g�steren sistemik lupus eritematozus olgusu

Naciye Demirel Y�ld�r�m¹, Demet Ayd�n¹, Meral Mert², Sava� Tuna³, Ercan B��akc�⁴, Meliha Nal�ac�⁴, �ner Do�an⁵
¹Okmeydan� E�itim ve Ara�t�rma Hastanesi, �� Hastal�klar�, Hematoloji B�l�m�, �stanbul
²Okmeydan� E�itim ve Ara�t�rma Hastanesi, �� Hastal�klar� Klini�i, �stanbul
³�stanbul E�itim ve Ara�t�rma Hastanesi, �� Hastal�klar� Klini�i, �stanbul
⁴�stanbul �niversitesi �stanbul T�p Fak�ltesi, �� Hastal�klar� Anabilim Dal�, Hematoloji Bilim Dal�, �stanbul
⁵�stanbul �niversitesi �stanbul T�p Fak�ltesi, Patoloji Anabilim Dal�, �stanbul

Sistemik lupus eritematozus (SLE), n�kleer antijenlere kar�� do�rudan oto-antikor geli�imi ile kendini g�steren, otoimm�n k�kenli ve klinik olarak heterojen bir hastal�kt�r. SLE bir�ok sistem ve organ tutulumu ile kendini g�sterebilir. En yayg�n bulgular ra�, artrit, halsizlik, nefrit ve n�rolojik bulgulard�r. Ancak anemi, trombositopeni, lokalize veya yayg�n lenfadenomegali de SLE�li hastalarda g�r�lebilen bulgulard�r. Bu yaz�da, derin anemi, yayg�n lenfadenomegali ve kilo kayb� ile hematoloji poliklini�imize m�racaat etmi�, yap�lan incelemeler sonucunda SLE tan�s� konmu� olan 17 ya��nda bir kad�n hasta bildirilmi�tir.

Anahtar Kelimeler: Anemi, lenfadenomegali, sistemik lupus eritematozus

Systemic lupus erythematosus presenting with severe anemia and generalized lymphadenomegaly

Naciye Demirel Y�ld�r�m¹, Demet Ayd�n¹, Meral Mert², Sava� Tuna³, Ercan B��akc�⁴, Meliha Nal�ac�⁴, �ner Do�an⁵
¹Okmeydani Training and Resarch Hospital, Department of Internal Medicine, Division of Hematology, Istanbul, Turkey
²Okmeydani Training and Resarch Hospital, Department of Internal Medicine, Istanbul, Turkey
³Istanbul Training and Resarch Hospital, Department of Internal Medicine, Istanbul, Turkey
⁴Istanbul University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Istanbul, Turkey
⁵Istanbul University Faculty of Medicine, Department of Pathology, Istanbul, Turkey

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease, which is autoimmune in origin and is characterized by the presence of autoantibodies directed against nuclear antigens. SLE can affect every organ in the body and is a multi-system disease. The most common manifestations include rash, arthritis, fatigue, nephritis, and neurological problems. However, anemia, thrombocytopenia, and localized or generalized lymphadenopathy are uncommon symptoms in this disease. Here, we present a 17-year-old female patient who was diagnosed as SLE based on the results of the performed investigations who presented with profound anemia, generalized lymphadenopathy and weight loss.

Keywords: Anemia, lymphadenomegaly, systemic lupus erythematosus

Sorumlu Yazar: Naciye Demirel Y�ld�r�m, T�rkiye
Makale Dili: T�rk�e

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