NÖTROPENÝK HASTALARDA BARSAKTA KOLONÝZE OLAN BAKTERÝLERÝN ANTÝBÝYOTÝK DUYARLILIK PROFÝLLERÝ

Hematolojik malignensisi olan ve hastanede yatan, nötropenik süreçteki 52 hastaya ait 188 dýþký örneðinden üretilen bakterilerin duyarlýlýk profilleri incelendi. Hastanede yattýðý sürece her hastadan haftada iki kez alýnan dýþký örneklerinden izole edilen bakteriler tanýmlanarak Kirby-Bauer disk diffüzyon yöntemiyle antibiyotik duyarlýlýk deneyleri yapýldý. 49 hastaya ait 168 dýþký örneðinden test edilen antibiyotiklere dirençli mikroorganizmalar izole edildi. 28 hastada persistan kolonizasyon saptandý. En sýk izole edilen bakteriler enterokok (%44.2) ve E.coli (%43.6)'ler olup, E. coli'nin bazý suþlarý dýþýndaki tüm izolatlar çeþitli antibiyotiklere dirençli bulundu. Çalýþmamýzda ayrýca hastanede yatan ancak nötropenik olmayan 76 hasta ve ayaktan tedavi gören 52 hastaya ait dýþký örnekleri de izolatlarýn antibiyotik duyarlýlýk profillerinin karþýlaþtýrýlmasý amacýyla incelendi. Sonuç olarak; nötropenik süreçte olan hastalardan üretilen bakterilerde direnç oranýnýn diðer gruplara göre daha fazla olduðu saptandý. Ýmmündüþkün olan ve çeþitli antibiyotiklere dirençli mikroorganizmalar ile kolonize olan bu grupta rutin dýþký kültürü ve antibiyogramm yapýlmasýnýn önemli olduðu kanýsýna varýldý.

ANTIBIOTIC SUSCEPTIBILITY PATTERNS OF BACTERIA COLONIZED IN THE INTESTINE OF NEUTROPENIC PATIENTS

Antibiotic susceptibility patterns of bacteria colonized in the intestine of neutropenic patients 188 fecal specimens of 52 neutropenic patients with haematological malignancies were microbiologically examined for the presence of antibiotic resistant bacteria. The microorganisms were isolated from the specimens that were taken twice a week and antibiotic susceptibility tests were performed by using Kirby-Bauer disk diffusion method.. Resistant microorganisms to various antibiotics, were isolated from 168 fecal specimens of 49 patients. Persistant colonization were found in 28 patients. The most frequent isolates were enterococci (44.2%) and E.coli (43.6%) and all isolates rather than some strains of E.coli were found to be resistant to various antibiotics. Besides the examination of fecal specimens taken from neutropenic and hospitalized patients; in our study 76 non-neutropenic hospitalized and 52 non-hospitalized patients were taken in study to compare the antibiotic susceptibility patterns. As a result, colonization with resistant microrganisms was higher in neutropenic patients than other groups. We conclude that; routine stool culturing and antibiotic susceptibility testing is important for this immuncompromised group; as they may be colonized with resistant microorganisms.