South Clin Ist Euras. 2013; 24(3): 151-156 | DOI: 10.5505/jkartaltr.2013.60476

Yardýmcý Üreme Teknikleriyle Elde Edilen Çoðul Gebeliklerin Perinatal Akýbeti

Zehra Sema Özkan, Remzi Atýlgan, Hasine Atlý, Raþit Ýlhan, Mehmet Þimþek, Ekrem Sapmaz
Fýrat Üniversitesi Týp Fakültesi Kadýn Hastalýklarý Ve Doðum Anabilim Dalý

AMAÇ: Yardýmcý üreme teknikleri (YÜT) ile elde edilen çoðul gebeliklerin, spontan çoðul gebeliklerden perinatal özellikler bakýmýndan bir fark gösterip göstermediðini araþtýrmayý amaçladýk.
YÖNTEMLER: Bu retrospektif kesitsel çalýþmada 2010-2013 yýllarý arasýnda doðum yaptýrýlan 54 çoðul (53 ikiz, 1 üçüz) gebelik vakasýnýn perinatal özellikleri incelendi.
BULGULAR: Ortalama anne yaþý, gravida ve parite sýrasýyla 29.5±5.8 yýl, 2.1±1.7 adet ve 1±1.7 adet idi. Gebeliklerin %68.5’ i spontan, %25.9’ u intrasitoplazmik sperm injeksiyonu-embriyo transferi (ICSI/ET) sonrasý ve %5.6’ sý intrauterin inseminasyon sonrasý idi. Vakalarýn %35.2’sine tokoliz ve %50’sine prepartum betametazon uygulandý. YÜT çoðul gebeliklerinde uygulanan tokoliz oraný, spontan çoðul gebeliklerden yüksek idi (%58.8 vs %24.3, p=0.01). YÜT çoðul gebeliklerinde diyetle regüle gestasyonel diabet oraný yüksek ( %17.6 vs %2.7) iken; tiroid disfonksiyon oraný ise daha düþük (%5.9 vs %13.5) idi.
SONUÇ: Bizim çalýþma popülasyonumuzda YÜT çoðul gebeliklerinde preterm eylem geliþme riski, spontan çoðul gebeliklere kýyasla daha yüksek oranda gözlendi.

Anahtar Kelimeler: çoðul gebelik, yardýmcý üreme teknikleri, spontan gebelik, perinatal akýbet

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Perinatal outcomes of multiple pregnancies after assisted reproductive technology

Zehra Sema Özkan, Remzi Atýlgan, Hasine Atlý, Raþit Ýlhan, Mehmet Þimþek, Ekrem Sapmaz
Fýrat Unýversýty School Of Medýcýne Department Of Obstetrýcs And Gynecology

OBJECTIVE: To investigate the difference between the perinatal outcomes of multiple pregnancies according to methods of conception: spontaneous versus assisted reproductive technology (ART).
METHODS: This retrospective cross-sectional study was conducted with 54 multiple pregnancies (1 triplet, 53 twins) whom were delivered between 2010 and 2013. Perinatal characteristics of all cases were collected from patient files and delivery records.
RESULTS: The mean maternal age, gravida and parity number of all women were 29.5±5.8 years, 2.1±1.7 and 1±1.7 respectively. The conception route of pregnancies were as follows: 68.5% with spontaneous conception, 25.9% with intracytoplasmic sperm injection- embryo transfer (ICSI/ET) and 5.6% with intrauterine insemination. Tocolytic medication was applied to 35.2% of pregnants and antenatal betamethasone was applied to 50% of cases. The rate of tocolytic medication was higher in ART multiple pregnancies than in spontaneous conception (58.8% vs 24.3%, p=0.01). While the rate of gestational diabetes mellitus was high (17.6% vs 2.7%), the rate of thyroid dysfunction was low (5.9% vs 13.5%) in ART multiple pregnancies.
CONCLUSION: In our population, the risk of preterm labor was significantly high in multiple pregnancies after ART compared to spontaneous multiple pregnancies.

Keywords: multiple pregnancy, assisted reproductive technology, spontaneous conception, perinatal outcome

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ATIF KOPYALA