TÝROÝDEKTOMÝNÝN KEMÝK MÝNERAL DANSÝTESÝ ÜZERÝNE ETKÝSÝ

DEXA (dual energy x-ray absorptiometry) yöntemi ile kemik mineral dansiteleri ölçülen 176 hastada, subtotal tiroidektomi geçiren ve hormonal suplemantasyon alan 24 hasta ve kontrol grubunu oluþturan 152 hasta gebelik, parite, yaþ, tüm vücut kemik mineral dansitesi (TVKMD), lumbal 2-4 kemik mineral dansitesi (L2-4KMD), femur boynu kemik mineral dansitesi (FBKMD) açýsýndan karþýlaþtýrýldý. Trioidektomi geçirmiþ hormonal suplemantasyon alan hastalarda yaþ ve gebelik ortalamalarý kontrol grubuna göre anlamlý ölçüde daha yüksek bulundu (p<0.05). Tiroidektomi geçirmiþ hormonal suplemantasyon alan hastalar ile kontrol grubundaki hastalanýl TVKMD, L2-4KMD, FBKMD deðerleri karþýlaþtýrýldýðýnda aralarýnda istatiksel bir anlamlýlýk bulunmadý (p>0.05).Çalýþmamýz subtotal tiroidektomi sonrasýnda yapýlan fizyolojik dozdaki tiroid hormon suplemantasyonunun, hastalarý vücuttaki hipertiroid ortamýn osteoporoz yapýcý etkisinden koruyacaðýný ve bu hastalarýn postmenopozal dönemde normal hastalardan daha yüksek bir risk altýnda olmayacaðýný düþündürdü.

EFFECTS OF THYROIDECTOMY ON BONE, MINERAL DENSITY

The bone mineral density levels of 176 patients were measured by the DEXA (dual energy x-ray absorptiometry) method. First group consisted of 24 patients in whom subtotal thyroidectomy had been performed and was now receiving hormonal replacement. Second, namely, the control group consisted of 152 patients. Parameters like age, pregnancy, parity, whole body bone mineral dansity (TVKMD), lumbal spine 2-4 bone mineral density (L2-4KMD), femoral neck bone mineral density (FBKMD) values were compared between these two groups. Mean values of age and pregnancy were significantly higher in the subtotal thyroidectomy and hormonal replacement group (p<0.05). Compared with the TVKMD, L2-4KMD, FBKMD values, there was no significant difference between the subtotal thyroidectomy and hormonal replacement group and the control group (p>0.05). If physiologic doses of thyroid hormone replacement are achieved after the subtotal thyroidectomy, the body can be prevented from the osteoporosis causing effect of the hyperthyroid environment. In this group of patients there wouldn't be any additive risk of fracture in the postmenopausal period.