Kemoterapi ve radyoterapi sonrasýnda geliþen Stevens-Johnson sendromlu bir olgu

Stevens-Johnson sendromu yüksek ateþ, pürülan konjunktivit, eroziv stomatit ve jeneralize ekzantemli cilt lezyonlarý ile kendini gösteren bir hastalýktýr. Etyolojide özellikle ilaçlar, enfeksiyon ajanlarý, karsinomlar, lösemiler ve kollajen doku hastalýklarý gibi pek çok faktörün rol oynadýðý bilinmektedir. Radyoterapi bu hastalýðýn etyolojisinde yer alan nadir nedenlerden biridir. Ancak radyoterapinin tek baþýna bir etken olup olmadýðý konusu henüz daha aydýnlatýlmamýþtýr. Nazofarenks epidermoid karsinomu nedeniyle dosetaksel ve sisplatin kemoterapisi ile eþ zamanlý radyoterapi alan ve radyoterapinin
34. gününde özellikle radyasyon uygulanan bölgede baþlayarak tüm vücuda yayýlan eritem, bül, yer yer erode alanlar ve hemorajik kurutlar, konjuktival hiperemi geliþen
hastayý sunuyoruz.

A case with Stevens-Johnson syndrome after chemotherapy and radiotherapy

Stevens-Johnson syndrome is a disease characterized by fever, purulent conjunctivitis, erosive stomatitis, and skin lesions with generalized exanthem. Many factors including drugs, infectious agents, carcinomas, leukemias, and collagen tissue diseases are known to play a role in its etiology. Radiotherapy is one of the factors that rarely has a part in the etiology of this disease. However, it is not clear whether radiotherapy is an etiological factor in and of itself. We present a case who had been receiving radiotherapy concurrently with docetaxel and cisplatin chemotherapy for epidermoid carcinoma. The patient developed erythema, bullae and occasional eroded areas that started at the site of radiation on the 34th day of radiotherapy and spread to the whole body, as well as hemorrhagic crusts and conjunctival hyperemia.