Antýhýpertansýf Tedavide Doksazosýn, Amlodipin Ve Ramipril'in Kan Lipid Profili Ve Kan Glukoz Düzeyine Etkilerinin Karþýlaþtýrýlmasý

Antihipertansif ilaçlardan alla-1 bloker olan Doksazosin, Angiotensin Konverting Enzim (ACE) Ýnhibilörii olan Ranýipýil ve Kalsiyum Kanal Blokeri olan Amlodipin'in tedavi dozlarýnda h i pcrtansif hastalarda antihipertansif etkinlikleri, kan glukoz düzeyi ve lipid profili üzerine etkileri karþýlaþtýrýlmýstýr. Çalýþma, Ocak 1996-Haziran 199f> talihleri arasýnda, hastanemizin Dahiliye Kliniði ve Polikliniðine baþvuran toplam 72 hasta üzerinde yapýlmýþtýr.Hastalara üç aylýk tedavi verilmiþ, tedavi öncesi ve üç ay sonunda telekardiografi, EKG, açlýk kan þekeri(AKÞ), ALT, AST, total kolesterol, trigliserid, H D L-kolesterol, üre, kreatinin düzeylerine bakýlmýþtýr. Çalýþmada tüm sonuçlar ortalama±SD olarak verilmiþ olup anlamlýlýk analizinde Wilcoxon eþleþtirilmiþ iki ömek testi kullanýlmýþtýr. Doksazosin grubunun kan lipid profiline anlamlý olarak yararlý etkisinin olduðu, AKÞ düzeyindeki düþmenin ise anlamlý olmadýðý saptanmýþtýr. Amlodipin ve Ramipril'in gerek lipid profili gerekse AK.Þ düzeyi üzerine anlamlý bir etkilerinin olmadýðý saptanmýþtýr. Her üç grup antihipertansif ilaç kan basýncýný düþürmede etkili bulunmuþtur.

The Comparison Of The Effect Of Doxazosýn, Amlodipin And Ramipril On Blood Lýpýd Profile And Blood Glucose Level Durýng Antý Hypertansýve Therapy

Ýn tlüs study, the efficacy of Doxazosin, an alfa-1 blocker, Ramipril, an angiotensin converting enzyme ÝnhÝüitor and Amlodipine, a caleium-ehannel blocker on hypertension, plasma glucose levels and lipid profîles among hypertensive patients were investigated, The study was performed on paticnts who wcre admittcd to cliýýic and outpatient elinic of üýternal medicine betwecn January - June 1996. Duration of treatment was 12 wceks for each paticnt.Bcfore and at the end of 12 weeks treatment, telecardiography and elcetrocardiography ývcrc performed and also fasting plasma glucose, ALT, AST, total eholesterol. triglyccridc, HDL eholesterol, BUN and ercatinine were measured. Ali results were given as mean±SD and paired Wilcoxon test uscd for statistical analysis. Botlý Amplodipin and Ramipril had no bcnetlcial effects on lipid profile and blood glucose levels. Doxazosin uas effective on reducing lipid profîles signifkantly, but not on fasting plasma glucose levels. As a conclusion, vve fýuýnd that ali these three antihypertensive drugs were effective at reducing blood pressure.