THE EVALUATION OF THE IMMUNOTHERAPY OF HOUSE DUST MITES WITH SPESIFIC IGG4 IN EXTRENSEC ASTHMA OF CHILDREN

Spesific immunotherapy has been applied the 44 children with the diagnosis of bronchial asthma. An in vitro study is planned to investigate the mechanism of the spesific immunotheraphy. The outcome of the therapy is evaluated by the IgG4 levels obtained in 6 month - intervals for 2 years after the therapy. The blocker antibodies (IgG4) against various types of house dust mites like Dermatophoides Pteronsyssinus (MI) and Dermatophoides Farineas (M2) are studied. As a result of this study it is concluded that for in vitro evaluation of spescific immunotheraphy IgG4 levels are not reliable in the first 6 months of therapy.

ÇOCUKLARDAKÝ EKSTRENSEK ASTMANIN ÝMMUNOTERAPÝSÝNDE EV TOZU AKARLARI (D. PTERONYSSÝNUS, D. FARÝNAE)'NÝN SPESÝFÝK ÝGG4'LERLE DEÐERLENDÝRÝLMESÝ (ÖN RAPOR)

Astým bronþiyale tanýsý konan 44 çocuk hastanýn spesifik immunoterapisi yapýldý Spesifik immunoterapi yapýlan hastalarýn bu tedaviden in vitro olarak yararlandýklarým araþtýrmak için bir çalýþma yapýlmasýna baþlandý. Ýki yýl süreli ve altý aylýk aralýklarla yapýlan tetkiklerde tedavi sonucunu deðerlendirmek amacýyla ev tozu akarlarýndan Dermatophoides Pteronyssinus (M1) ve dermatophoides Farinea (M2) gibi akarlara karþý blokan antikor olarak adlandýrýlan spesifik IgG4 deðerlen araþtýrýldý. Bu çalýþma sonunda spesifik immunoterapide spesifik IgG4 deðerlerinin ilk altý ayda in vitro olarak yeterli bir deðerlendirme olmadýðý sonucuna ulaþýldý.