South Clin Ist Euras. 2023; 34(3): 214-219 | DOI: 10.14744/scie.2023.36036

Assessment of the Inflammatory Markers in Patients with First-episode Psychosis: A Comparative Study

Hidayet Ece Arat Çelik¹, Ayþe Ece Buyuksandalyaci Tunc¹, Burcu Kok Kendýrlýoglu¹, Buðra Çetin¹, Esma Corekli Kaymakci¹, Þevin Demir², Suat Kucukgoncu^1
1Maltepe University Faculty of Medicine, Department of Psychiatry, Ýstanbul, Türkiye
²Maltepe University Faculty of Medicine, Department of Family Medicine, Ýstanbul, Türkiye

INTRODUCTION: Recently, the importance of inflammatory processes in the etiology of psychotic disorders has been increasingly emphasized. The manner in which the inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR), are affected during psychotic disorders is unknown. This study aimed to compare the NLR, MLR, and PLR levels between patients with first-episode psychosis (FEP), patients with chronic psychotic disorder (CPD) and healthy controls (HC).
METHODS: This study included 36 patients with FEP, 57 patients with CPD, and 93 HC. The Kruskal-Wallis test was used for intergroup comparisons of inflammatory markers. Linear regression analysis was used to examine the extent to which the NLR levels were affected by age.
RESULTS: The NLR levels of patients diagnosed with CPD were higher than those diagnosed with FEP and HC. There was no difference between the NLR levels of patients with FEP and HC. Even after removing the age effect between the groups, there was a significant difference between the groups in terms of the NLR levels. However, there was no intergroup difference in the MLR and PLR levels.
DISCUSSION AND CONCLUSION: Higher NLR levels in patients with CPD than in patients with FEP and HC indicated that the inflammatory process was increased in psychotic disorders during the prognosis of the chronic disease. To further understand the underlying causes of psychotic disorder, additional longitudinal studies are required to identify the manner, in which inflammatory processes are impacted by the disorder.

Keywords: First-episode psychosis, inflammation, monocyte-to-lymphocyte ra-tio, neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; psychosis.

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Ýlk Epizod Psikoz Hastalarýnda Ýnflamasyon Belirteçlerinin Deðerlendirilmesi: Karþýlaþtýrmalý Çalýþma

Hidayet Ece Arat Çelik¹, Ayþe Ece Buyuksandalyaci Tunc¹, Burcu Kok Kendýrlýoglu¹, Buðra Çetin¹, Esma Corekli Kaymakci¹, Þevin Demir², Suat Kucukgoncu^1
1Maltepe Üniversitesi Týp Fakültesi, Psikiyatri Anabilim Dalý, Ýstanbul
²Maltepe Üniversitesi Týp Fakültesi, Aile Hekimliði Anabilim Dalý, Ýstanbul

GÝRÝÞ ve AMAÇ: Son yýllarda inflamatuvar süreçlerin psikotik bozukluklarýn etiyolojisindeki önemine yapýlan vurgu giderek artmaktadýr. Ýnflamatuvar belirteçlerden olan nötrofil lenfosit oraný (NLR), monosit lenfosit oraný (MLR) ve platelet lenfosit oranýnýn (PLR) psikotik bozuklukta hastalýk süresince ne yönde etkilendiði net olarak bilinmemektedir. Bu çalýþmanýn amacý, ilk atak psikoz hastalarýnýn, kronik psikotik hastalarýn ve saðlýklý kontrollerin NLR, MLR ve PLR düzeylerinin karþýlaþtýrýlmasýdýr.
YÖNTEM ve GEREÇLER: Çalýþmaya ilk kez psikotik atak geçiren 36 birey, kronik psikotik bozukluðu olan 57 birey ve 93 saðlýklý kontrol dahil edildi. Gruplar arasýnda inflamatuvar belirteçlerin karþýlaþtýrmasýnda Kruskal-Wallis Testi kullanýldý, ikili grup karþýlaþtýrmalarý Pairwise Analizi ile yapýldý. NLR deðerlerinin yaþtan etkilenme düzeyini belirlemek amacýyla lineer regresyon analizi uygulandý.
BULGULAR: Kronik psikotik bozukluk tanýlý bireylerin NLR düzeylerinin ilk atak psikoz tanýlý bireylerden ve saðlýklý kontrollerden yüksek olduðu saptandý. Ýlk atak psikoz tanýlý bireylerin NLR düzeyleri saðlýklý kontrollerden farklýlýk göstermedi. Gruplar arasýnda yaþýn etkisi ortadan kaldýrýldýðýnda NLR düzeyleri açýsýndan gruplar arasýndaki anlamlý farklýlýk korundu. MLR ve PLR düzeyleri gruplar arasýnda farklýlýk göstermedi.
TARTIÞMA ve SONUÇ: Kronik psikotik bozukluk tanýlý bireylerde ilk atak psikoz tanýlý bireylere ve saðlýklý kontrollere göre NLR düzeylerinin yüksek saptanmasý, psikotik bozuklukta inflamatuvar sürecin kronik süreçte arttýðýný göstermektedir. Uzunlamasýna yapýlacak çalýþmalarla psikotik bozukluk-ta inflamatuvar süreçlerin nasýl etkilendiðinin incelenmesi, hastalýða katký saðlayan faktörleri anlamak açýsýndan faydalý olacaktýr.

Anahtar Kelimeler: Ýlk atak psikoz, inflamasyon, nötrofil lenfosit oraný, monosit lenfosit oraný; platelet lenfosit oraný; psikoz.

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