South Clin Ist Euras. 2017; 28(2): 77-81 | DOI: 10.14744/scie.2017.93276

Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats

Hakan Akdere
Department of Urology, Trakya University Faculty of Medicine, Edirne, Turkey

INTRODUCTION: The aim of the present study was to evaluate the effect of fraction dose irradiation on kidney damage due to scattered radiation.
METHODS: Rats were randomized into 6 groups. Group 1: Control group, a sham irradiation (n=5); Group 2: Hypofractionated total abdominal irradiation (TAI), total of 12 Gy (2 fractions in 2 days) (n=4); Group 3: Hypofractionated TAI, total of 12 Gy (3 fractions in 3 days; n=6); Group 4: Hypofractionated TAI, total of 12 Gy (4 fractions in 4 days; n=6); Group 5: TAI with conventional fractionation, total of 12 Gy (6 fractions in 6 days; n=6); and Group 6: TAI with conventional fractionation, total of 12 Gy (7 fractions in 7 days; n=6).
RESULTS: There was no statistically significant difference (p>0.05) between the hypofractionated group sets of Groups 3-4 (2.66±0.51) and 5-6 (1.83±0.40). However, a statistically significant difference was found in the comparison between Group 2 (3.75±0.51) and the group sets of Groups 3–4 and 5–6 (p<0.05).
DISCUSSION AND CONCLUSION: The present study demonstrated that hypofractionated TAI leads to more prominent acute tissue damage in the kidneys than does conventional irradiation.

Keywords: Hypofractionated radiotherapy, irradiation damage, radiotherapy, renal tissue

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Sýçanlarda Böbrek Dokusunda Farklý Fraksiyon Þemalarýnda Uygulanan 12 Gy Radyoterapinin Yarattýðý Akut Etkilerin Histopatolojik Olarak Ýncelenmesi

Hakan Akdere
Trakya Üniversitesi Týp Fakültesi, Ana Bilim Dalý, Edirne, Türkiye

GÝRÝÞ ve AMAÇ: Amacýmýz aralýklý verilen fraksiyone doz radyoterapinin böbrek hasarýna etkisini incelemek.
YÖNTEM ve GEREÇLER: Sýçanlarda 6 gruba randomiz edildi: Grup 1: Kontrol; sham radyoterapi (n=5); Grup 2: Hipo-fraksiyone total abdominal radyoterapi (TAR); total 12 Gy (2 günde 2 fraksiyon) (n=4); Grup 3: Hipo-fraksiyone TAR; total 12 Gy (3 günde 3 fraksiyon; n=6); Group 4: Hipo-fraksiyone TAR; total 12 Gy (4 günde 4 fraksiyon; n=6); Group 5: konvansiyonel ayýrma ile TAR; total 12 Gy (6 günde 6 fraksiyon; n=6); ve Group 6: konvansiyonel ayýrma ile TAR; total 12 Gy (7 günde 7 fraksiyon; n=6).

BULGULAR: Hipofraksiyone gruplar 3 ile 4 (2.66±0.51) ve grup 5 ile 6 (1.83±0.40) arasýnda istatistiksel olarak anlamlý fark tespit edilmezken grup 2 (3.75±0.51) ile grup 3–4 ve grup 5–6 arasýnda istatistiksel olarak anlamlý fark tespit edilmiþtir (p<0.05).

TARTIÞMA ve SONUÇ: Bu çalýþmamýz hipo-fraksiyone total abdominal radyoterapini, böbreklerde akut doku hasarýna konvansiyonel radyoterapiye göre daha belirgin þekilde yol açtýðýný göstermiþtir.

Anahtar Kelimeler: Böbrek dokusu, hipo-fraksiyone radyoterapi, radyasyon hasarý, radyoterapi.

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