South Clin Ist Euras. 2025; 36(2): 189-195 | DOI: 10.14744/scie.2025.54280

Patients with a Resected Pancreatic Cystic Neoplasm: A Single Center 10-Year Experience

Zehra Zeynep Keklikkiran¹, Ezgi Tatlisu², Fatih Feratoglu³, Muhammed Ali Ozdemir⁴, Hasan Fehmi Kucuk^5
1Department of Gastroenterologic Surgery, Rize Recep Tayyip Erdogan University Research and Training Hospital, Rize, Türkiye
²Department of Gastroenterologic Surgery, Kayseri City Hospital, Kayseri, Türkiye
³Department of General Surgery, Sultanbeyli State Hospital, Istanbul, Türkiye
⁴Rize Recep Tayyip Erdogan University Faculty Of Medicine, Rize, Türkiye
⁵Department of General Surgery, Istanbul Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Türkiye

INTRODUCTION: Pancreatic cystic neoplasia represents a challenging and complex spectrum of lesions within the pancreas and requires a detailed understanding of their biological behavior and clinical implications. We aimed to examine the demographic characteristics, imaging and histopathological features, and clinical outcomes of patients who underwent pancreatic surgery due to cystic neoplasms. Moreover the impact of sarcopenia and obesity on clinical outcomes was investigated.
METHODS: Patients who underwent pancreatic surgery with the preliminary diagnosis of pancreatic cystic neoplasia at the General Surgery Clinic of Kartal Dr. Lütfi Kýrdar City Hospital between 2010 and 2020 were retrospectively evaluated. The size, morphological features, location, and number of the cystic lesions were recorded. The presence of sarcopenia was determined by measuring the psoas muscle cross-sectional area at the L3 level with
preoperative CT and calculating the psoas muscle index.
RESULTS: The number of patients included in the study was 23 and the average age of these patients was 59.4 (SD: 14.3). 18 (78.3%) of the patients were women. The most common cyst type was mucinous cystic neoplasia (30.4%), followed by an adenoma (26%), ductal adenocarcinoma (26%) and IPMN (17.3%). The most common surgery was the Whipple procedure (56.5%). Sarcopenia was detected in 47.8% of the patients. Postoperative omplications were seen in 6 (26%) patients.
DISCUSSION AND CONCLUSION: This study provides valuable information regarding pancreatic cystic neoplasms’ pathological and clinical consequences. In particular, it is one of the few studies investigating the relationship between sarcopenia, obesity and pancreatic cystic neoplasms in the current literature.

Keywords: Obesity, pancreatectomy, pancreatic cystic neoplasm, postoperative complications, sarcopenia.

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Pankreatik Kistik Neoplazm Tanýsýyla Rezeksiyon Yapýlmýþ Hastalar: Tek Bir Merkezde 10 Yýllýk Deneyim

Zehra Zeynep Keklikkiran¹, Ezgi Tatlisu², Fatih Feratoglu³, Muhammed Ali Ozdemir⁴, Hasan Fehmi Kucuk^5
1
2
3
4
5

GÝRÝÞ ve AMAÇ: Pankreatik kistik neoplazi, pankreas içindeki lezyonlarýn zorlu ve karmaþýk bir spektrumunu temsil eder ve biyolojik davranýþlarýnýn ve klinik etkilerinin ayrýntýlý bir þekilde anlaþýlmasýný gerektirir. Kistik neoplazmlar nedeniyle pankreas cerrahisi geçiren hastalarýn demografik özelliklerini, görüntüleme ve histopatolojik özelliklerini ve klinik sonuçlarýný incelemeyi amaçladýk. Ayrýca sarkopeni ve obezitenin klinik sonuçlar üzerindeki etkisi de araþtýrýldý.
YÖNTEM ve GEREÇLER: Kartal Dr. Lütfi Kýrdar Þehir Hastanesi Genel Cerrahi Kliniði’nde 2010-2020 yýllarý arasýnda pankreatik kistik neoplazi ön tanýsý ile pankreas cerrahisi uygulanan hastalar retrospektif olarak deðerlendirildi. Kistik lezyonlarýn boyutu, morfolojik özellikleri, yerleþimi ve sayýsý kaydedildi. Sarkopeni varlýðý, ameliyat öncesi BT ile L3 seviyesinde psoas kas kesit alaný ölçülerek ve psoas kas indeksi hesaplanarak belirlendi.
BULGULAR: Çalýþmaya dahil edilen hasta sayýsý 23 ve bu hastalarýn yaþ ortalamasý 59.4 (SD: 14.3) idi. Hastalarýn 18’i (%78.3) kadýndý. En sýk görülen kist tipi müsinöz kistik neoplazi (%30.4) iken, bunu adenom (%26), duktal adenokarsinom (%26) ve IPMN (%17.3) izlemekteydi. En yaygýn ameliyat Whipple prosedürüydü (%56.5). Hastalarýn %47.8’inde sarkopeni tespit edilmiþtir. Ameliyat sonrasý komplikasyonlar 6 (%26) hastada görüldü.
TARTIÞMA ve SONUÇ: Bu çalýþma pankreatik kistik neoplazmlarýn patolojik ve klinik sonuçlarý hakkýnda deðerli bilgiler saðlamaktadýr. Özellikle, mevcut literatürde sarkopeni, obezite ve pankreatik kistik neoplazmlar arasýndaki iliþkiyi araþtýran az sayýdaki çalýþmadan biridir.

Anahtar Kelimeler: Komplikasyonlar, obezite, pankreatektomi, pankreatik kistik neoplazi, postoperatif sarkopeni.

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