South Clin Ist Euras. 2025; 36(2): 121-130 | DOI: 10.14744/scie.2025.87003

The Effect of Dextran on Colonic Anastomoses During The Early Postoperative Period in Rats

Oðuzhan Alp Öztürk¹, Ezgi Genç Erdoðan², Zeliha Türkyýlmaz^1
1Department of General Surgery, Trakya University Medical Faculty, Edirne, Türkiye
²Department of Pathology, Trakya University Medical Faculty, Edirne, Türkiye

INTRODUCTION: Anastomotic leakage after colorectal surgery is a serious complication associated with high mortality. Dextran has been reported to reduce blood viscosity and increase microcirculation. This study was conducted to investigate whether postoperative dextran infusion contributes to anastomotic durability.
METHODS: A total of 40 Wistar Albino rats were used in the study. There are two experimental groups that received Dextran for 3 and 7 days after colon anastomosis and two control groups that did not receive any treatment. Anastomotic burst pressure score was calculated. Anastomosis healing parameters were evaluated histopathologically.
RESULTS: The median bursting pressure observed with the inflammatory phase experiment group was significantly higher than the inflammatory phase control group (p=0.001). Mucosal re-epithelialization was higher than the control groups in both the inflammatory phase (p=0.005) and the proliferative phase (p=0.007).
DISCUSSION AND CONCLUSION: Dextran could be considered as a potential treatment for anastomosis protection due to its positive effect on mucosal re-epithelialization and especially its increase in premature burst pressure.

Keywords: Anastomosis, anastomotic leak, bursting pressure, colon, dextran.

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Sýçanlarda Erken Postoperatif Dönemde Kolon Anastomozlarý

Oðuzhan Alp Öztürk¹, Ezgi Genç Erdoðan², Zeliha Türkyýlmaz^1
1
2

GÝRÝÞ ve AMAÇ: Kolorektal cerrahiden sonra anastomoz sýzýntýsý yüksek mortalite ile iliþkili ciddi bir komplikasyondur. Dekstranýn kan viskozitesini azalttýðý ve mikrosirkülasyonu artýrdýðý bildirilmiþtir. Bu çalýþma, postoperatif dekstran infüzyonunun anastomoz dayanýklýlýðýna katkýda bulunup bulunmadýðýný araþtýrmak için yürütülmüþtür.
YÖNTEM ve GEREÇLER: Çalýþmada toplam 40 Wistar Albino sýçaný kullanýlmýþtýr. Kolon anastomozundan sonra 3 ve 7 gün boyunca Dekstran alan iki deney grubu ve herhangi bir tedavi almayan iki kontrol grubu bulunmaktadýr. Anastomoz patlama basýncý skoru hesaplanmýþtýr. Anastomoz iyileþme parametreleri histopatolojik olarak deðerlendirilmiþtir.
BULGULAR: Ýnflamatuvar faz deney grubunda gözlenen medyan patlama basýncý, inflamatuvar faz kontrol grubundan anlamlý derecede yüksekti (p=0.001). Mukozal re-epitelizasyon, hem inflamatuvar fazda (p=0.005) hem de proliferatif fazda (p=0.007) kontrol gruplarýndan daha yüksekti.
TARTIÞMA ve SONUÇ: Dekstran, mukozal re-epitelizasyon üzerindeki olumlu etkisi ve özellikle erken patlama basýncýný artýrmasý nedeniyle anastomoz korumasý için potansiyel bir tedavi olarak düþünülebilir.

Anahtar Kelimeler: Anastomoz, anastomoz sýzýntýsý, dekstran, kolon, patlama basýncý.

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