VÝRAL HEPATÝTLÝ OLGULARDA SERUM PREALBUMÝN DÜZEYLERÝ

Bu çalýþma viral hepatitli olgularda serum prealbumin düzeylerini saptamak ve bu düzeylerin viral hepatitin tanýsýndaki deðerlerini araþtýrmak amacýyla yapýlmýþtýr. Bu amaçla 38 viral hepatitli olguda ve 32 saðlýklý kontrol olgusunda serum prealbumin düzeyleri, serum AST, ALT, GGT, ALP, total protein, albumin, total bilirubin ve direkt bilirubin düzeyleri ile birlikte tayin edilmiþtir. Kontrol gurubunda prealbumin düzeyleri 19.10-37.50 (28.96±6.18 mg/dl)olarak saptanmýþtýr Oysa viral hepatitli olgularda ise 3.3-23.0, 9.60±7.06 mg/dl olarak bulunmuþtur. Akut viral olgularda kontrol grubuna kýyasla serum prealbumin seviyelerinde belirgin bir düþme saptanmýþtýr. Bu düþme istatistiksel olarak anlamlý bulunmuþtur. (p<0.001). Viral hepatitli olgularda hastalýðýn baþlangýç döneminde serum pre albumin düzeylerinde saptanan düþme, tayin edilen diðer parametrelerde görülen deðiþmelerle uyumludur. Bu çalýþma ile elde edilen verilerden serum prealbumin tayinlerinin akut viral hepatitin tanýsýnda yararlý olabileceði kanýsýna varýlmýþtýr.

SERUM PREALBUMIN LEVELS IN VIRAL HEPATITIS CASES

This study was undertaken to find the serum prealbumin levels in cases of viral hepatitis and to investigate the importance of these levels for diagnosis of viral hepatitis. Serum prealbumin levels were estimated in 38 cases of acute viral hepatitis and 32 healthy controls along with serum AST, ALT, GGT, ALP, total protein, albumin, total bilirubin and direct bilirubin. Serum prealbumin level in control group was found 19.10-37.50, 28.96±6.18 mg/dl (mean ±SD), whereas this level in the cases of acute viral hepatitis was found 3.3-23.0, 9.60±7.06 mg/dl. In the cases of acute viral hepatitis, a certain increase was observed by comparison with the control group. This increase was found statistically significant (p<0.001). The increase of serum prealbumin level observed in the initial phase of illness was correlated with other parameters investigated. It was concluded that serum prealbumin estimation may be useful parameter in viral hepatitis.