South Clin Ist Euras. 2017; 28(1): 22-26 | DOI: 10.14744/scie.2016.03264

First Trimester Renin and Aldosterone Levels of Pregnant Women With Prognosis of Preeclampsia and/or Related Adverse Pregnancy Outcomes

Yunus Emre Purut¹, Ayþe Yasemin Karageyim Karþýdað², Esra Esim Büyükbayrak³, Asuman Orçun⁴, Mehmet Menke^4
1Department of Obstet & Gynecol, Boyabat 75. Year Hospital, Sinop, Turkey
²Department of Health Sciences, Kýrklareli University, Kýrklareli, Turkey
³Department of Obstet & Gynecol, Marmara University Pendik Training and Research Hospital, Ýstanbul, Turkey
⁴Department of Biochemistry, Kartal Dr. Lütfi Kýrdar Training and Research Hospital, Ýstanbul, Türkiye

INTRODUCTION: To evaluate first trimester renin and aldosterone levels of pregnancies complicated with preeclampsia and/or related adverse pregnancy outcomes.
METHODS: We measured serum levels of renin and aldosterone for pregnant women for first trimester screening test. One hundred eighty pregnant women were included the study and 140 of them completed the study. All pregnant women were followed during pregnancy for developing preeclampsia and related complications. Renin and aldosterone levels of preeclampsia and/or developing poor obstetric groups compared with normal pregnancy outcome group.
RESULTS: Preeclampsia developed in 13 pregnant women and one or more poor obstetric outcomes developed in 36 women. Renin and aldosterone levels were not significantly different in preeclamptic women or pregnancy with poor obsteric outcome groups compared with control.
DISCUSSION AND CONCLUSION: We suggest that maternal first trimester renin and aldosterone levels may not play a role in the pathogenesis and prediction of gestational hypertension.

Keywords: Aldosterone, preeclampsia, poor obstetric prognosis, renin

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Preeklampsi ve Ýliþkili Kötü Obstetrik Prognoz Geliþen Gebelerde Birinci Trimester Renin ve Aldosteron Düzeyleri

Yunus Emre Purut¹, Ayþe Yasemin Karageyim Karþýdað², Esra Esim Büyükbayrak³, Asuman Orçun⁴, Mehmet Menke^4
1Kadýn Hastalýklarý ve Doðum Kliniði, Boyabat 75. Yýl Devlet Hastanesi, Sinop, Türkiye.
²Kýrklareli Üniversitesi, Kýrklareli, Türkiye.
³Kadýn Hastalýklarý ve Doðum Kliniði, Marmara Üniversitesi Pendik Eðitim ve Araþtýrma Hastanesi, Ýstanbul, Türkiye.
⁴Biyokimya Kliniði, Dr. Lütfi Kýrdar Kartal Eðitim ve Araþtýrma Hastanesi, Ýstanbul, Türkiye.

GÝRÝÞ ve AMAÇ: Preeklampsi ve iliþkili kötü obstetrik prognoz geliþen gebelerde birinci trimester renin ve aldosteron düzeylerini belirlemek.
YÖNTEM ve GEREÇLER: Birinci trimester taramasý için kan veren gebelerde renin ve aldosteron düzeylerine bakýldý. Çalýþmaya 180 hasta alýndý, hastalardan 144’ü çalýþmayý tamamladý. Gebeler doðuma kadar preeklampsi ve kötü obstetrik prognoz geliþimi için izlendi. Preeklampsi ve kötü obstetrik prognoz geliþen gebelerin sonuçlarý normal gebelik seyri olan grupla karþýlaþtýrýldý.
BULGULAR: Hastalarýn 13’ünde preeklampsi, 36’sýnda ise bir veya daha fazla kötü obstetrik sonuç geliþti. Peeklampsi ve kötü obstetrik sonuç geliþen olgular ile geliþmeyen olgularýn renin ve aldosteron düzeyleri karþýlaþtýrýldýðýnda istatistiksel olarak anlamlý bir fark saptanmadý.
TARTIÞMA ve SONUÇ: Birinci trimester renin ve aldosteron düzeylerinin preeklampsi etiyolojisi ve öngörüsünde yeri olmadýðýný düþünmekteyiz.

Anahtar Kelimeler: Aldosteron, kötü obstetrik prognoz, preeklampsi, renin.

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